Camille Merckx received a degree in musicology from La Sorbonne with top honours and was unanimously awarded the Paris CNR Higher Education for Young Singers Prize for Further Education. She then joined the Queen Elizabeth Musical Chapel opera studio in partnership with the Théâtre de la Monnaie in Bruxelles. Her professional career began with the role of The Sorceress in Dido and Aeneas at the 2004 Automne Festival in Normandy. She went on to embody Suor Zelatrice in Suor Angelica, La Folie in Destouches’ Le Carnaval et la Folie at the Opéra Comique, Nicklaus and La Mère in Les contes d’Hoffmann, Dryade in Ariadne auf Naxos at the Théâtre de l'Athénée in Paris and Flosshilde in Der Ring des Nibelungen at the Teatro Valli.

In 2010, she made her debut at La Monnaie as Garcias in Don Quichotte, the lady of honour in Les Huguenots, Musico in Manon Lescaut. In 2014, she made her debut in Switzerland as Mercedes in Carmen at the Avenches Opera Festival. She has also given recitals accompanied by piano or orchestra and has recently performed Mahler’s Das Lied von der Erde at the Nouveau Siècle in Lille. Contemporary music has played an important role in her repertoire for years. Amon others, she performed L'Oiseau in Bacri's Fleur et le miroir magique with the Lille Orchestra.